🩸 Chapter 522 · Plasma Transfusions

Nelson Textbook of Pediatrics 22nd Edition | Plasma transfusions (fresh frozen plasma — FFP, FFP24). Indications: bleeding with multiple clotting factor deficiencies (DIC, liver disease, massive transfusion), warfarin reversal (if prothrombin complex concentrate unavailable), TTP (plasma exchange), specific factor deficiencies when concentrate unavailable. Dose: 10-15 mL/kg. Not indicated for volume expansion or isolated prolonged PT/PTT without bleeding. Neonates: use age-adjusted normal ranges.

🌐 paeds.online — Pakistan's Pediatric Platform

📋 30 Clinical Scenarios — Plasma Transfusions

📇 High‑Yield Review Cards (Plasma Transfusions)

🩺 Clinical Scenarios: Plasma Transfusion Decisions

Select a presentation for transfusion guidance.

📋 Stepwise Management of Plasma Transfusions

🔑 Key Principles — Nelson Chapter 522
• Indications: Bleeding with multiple coagulation factor deficiencies (DIC, liver disease, massive transfusion, dilutional coagulopathy). Emergency reversal of warfarin (if PCC unavailable). Replacement of specific factor deficiencies (e.g., factor V, XI) when concentrates unavailable. Plasma exchange for TTP.
• Not indicated: Volume expansion, correction of isolated prolonged PT/PTT without bleeding (especially in neonates with physiologic prolongation), routine prophylaxis in non-bleeding patients.
• Dose: 10-15 mL/kg (raises clotting factors by ~20-30%).
• Products: FFP (frozen within 8 hours) or FFP24 (frozen within 24 hours) — equivalent for most indications.
• Neonates: Use age-adjusted normal ranges; do not transfuse for physiologic prolongation.

    ⚡ Reflex Prompts — Clinical Decisions in Plasma Transfusion

    📖 Summary: Plasma Transfusions — Nelson Chapter 522