🩸 Chapter 556 · Histiocytosis Syndromes of Childhood (LCH & HLH)

Nelson Textbook of Pediatrics 22nd Edition | Comprehensive coverage: Langerhans cell histiocytosis (LCH, CD1a+, langerin+, BRAF V600E, MAPK pathway), hemophagocytic lymphohistiocytosis (HLH, primary/familial, secondary, HLH-2004 criteria, perforin/MUNC13-4, cytokine storm, etoposide, emapalumab), Erdheim-Chester, Rosai-Dorfman, and targeted therapy (vemurafenib, sirolimus).

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πŸ“‹ 30 Clinical Scenarios β€” Histiocytosis Syndromes (Nelson Ch 556)

πŸ“‡ High‑Yield Review Cards (Histiocytosis)

🩺 Symptom‑Based Approach: Recognizing Histiocytosis

Click any presentation for diagnostic reasoning based on Nelson Ch 556.

πŸ“‹ Stepwise Management of Histiocytosis Syndromes

    ⚑ Reflex Prompts β€” Histiocytosis Diagnosis & Treatment

    πŸ“– Summary: Histiocytosis Syndromes β€” Nelson 22e (Chapter 556)