🦠 Hepatitis A (HAV)

Nelson Textbook of Pediatrics 22nd Edition — Hepatitis A is an RNA virus (Picornaviridae) transmitted via fecal-oral route. Incubation 15-50 days. Diagnosis: anti-HAV IgM (acute infection). Self-limited, no chronic disease. Prevention: inactivated vaccine (≥12 months) and immune globulin for post-exposure prophylaxis. Supportive care for acute illness.

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📋 30 Clinical Scenarios — Hepatitis A

📇 High‑Yield Review Cards (Hepatitis A)

🩺 Clinical Presentations: Hepatitis A

Select a presentation for diagnostic clues and management.

📋 Stepwise Evaluation & Management of Hepatitis A

🔑 Key Principles — Hepatitis A (Nelson Ch.406)
• Transmission: Fecal-oral, person-to-person, contaminated food/water.
• Diagnosis: Anti-HAV IgM = acute infection (appears at symptom onset, persists 4-6 months). Anti-HAV IgG = past infection or vaccination.
• Clinical course: Incubation 2-6 weeks. Children often anicteric. Adults more likely jaundiced. Self-limited (2-8 weeks). Fulminant rare (<0.5%).
• Treatment: Supportive care (hydration, nutrition). No antiviral therapy.
• Prevention: Inactivated HAV vaccine (2 doses, 6-12 months apart, starting at 12-23 months). Immune globulin for post-exposure (within 14 days).

    ⚡ Reflex Prompts — Hepatitis A Clinical Decisions

    📖 Hepatitis A — Core Summary (Nelson Ch.406)