🍄 Chapter 285 · Blastomycosis (Blastomyces dermatitidis)

Nelson Textbook of Pediatrics 22nd Edition | Endemic in Great Lakes, Mississippi River, Ohio River valleys, and southeastern US. Pulmonary blastomycosis (acute or chronic pneumonia), disseminated disease (skin – verrucous or ulcerative lesions, bone – osteolytic, CNS – meningitis/abscess). Diagnosis: KOH preparation (broad-based budding yeast), culture, urine antigen (cross-reacts with Histoplasma). Treatment: itraconazole (mild-moderate), amphotericin B (severe, disseminated, CNS).