Nelson Textbook of Pediatrics 22nd Edition | Seven human coronaviruses: endemic (229E, OC43, NL63, HKU1) cause 15% of common colds; epidemic (SARS-CoV, MERS-CoV, SARS-CoV-2). SARS-CoV-2 (COVID-19) pandemic: children generally mild illness but can have severe disease, MIS-C (Multisystem Inflammatory Syndrome in Children). Treatment: supportive, remdesivir, dexamethasone. Prevention: vaccines (mRNA, adenovirus-vector).
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