Nelson Textbook of Pediatrics 22nd Edition | Early-onset (0-6 days) vs late-onset (7-90 days) neonatal disease, maternal colonization, intrapartum antibiotic prophylaxis (IAP), serotypes (Ia, Ib, II, III, IV, V), meningitis, sepsis, treatment, prevention.
๐ paeds.online โ Pakistan's Pediatric Platform| Feature | Early-Onset (0-6 days) | Late-Onset (7-90 days) |
|---|---|---|
| Peak age | 24-48 hours | 3-4 weeks |
| Maternal risk factors | GBS colonization, PROM, preterm, chorioamnionitis | None (horizontal acquisition) |
| Common syndromes | Sepsis, pneumonia, meningitis | Bacteremia, meningitis, osteomyelitis, cellulitis-adenitis |
| Mortality | ~4-5% | ~3% |
| Prevention | Intrapartum antibiotic prophylaxis (IAP) | No prevention (maternal vaccine in development) |