Nelson Textbook of Pediatrics 22nd Edition | Hantavirus pulmonary syndrome (HPS) is a severe cardiopulmonary illness caused by New World hantaviruses (e.g., Sin Nombre virus). Reservoir: deer mouse (Peromyscus maniculatus). Transmission: aerosolized rodent excreta. Clinical: febrile prodrome β rapid onset of noncardiogenic pulmonary edema, hypoxia, and shock. Key lab finding: thrombocytopenia. High mortality (~50%). No specific antiviral; intensive supportive care.
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