Nelson Textbook of Pediatrics 22nd Edition | Salmonella gastroenteritis, bacteremia, focal infections (osteomyelitis in sickle cell disease). High-risk groups (infants <3 months, immunocompromised, sickle cell). Treatment: supportive care for uncomplicated gastroenteritis; antibiotics for high-risk patients (azithromycin, ceftriaxone).
🌐 paeds.online — Pakistan's Pediatric Platform| Risk Group | Reason | Recommended Treatment |
|---|---|---|
| Infants <3 months | Increased risk of bacteremia/meningitis | IV ceftriaxone (or ampicillin + gentamicin) |
| Sickle cell disease | Risk of osteomyelitis, severe bacteremia | IV ceftriaxone for bacteremia; 4-6 w for osteomyelitis |
| Immunocompromised (HIV, malignancy, transplant) | Risk of disseminated disease | IV ceftriaxone or azithromycin |
| Prosthetic devices (central line, joint) | Risk of line infection | IV ceftriaxone + line removal |
| Severe disease (high fever, toxicity, bloody diarrhea, need for hospitalization) | Systemic illness | IV ceftriaxone or azithromycin |