Nelson Textbook of Pediatrics 22nd Edition | Neonatal HSV: acquired during delivery (most common), intrauterine, or postpartum. Categories: SEM (skin, eye, mouth) – 14 days IV acyclovir; CNS (encephalitis) – 21 days IV acyclovir; Disseminated (hepatitis, pneumonitis, DIC) – 21 days IV acyclovir. Prevention: Cesarean section for active genital lesions, acyclovir suppressive therapy at term. Diagnosis: PCR (blood, CSF, surface swabs). Mortality high without treatment.
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