🧬 Chapter 321 · Polyomaviruses (BK, JC)

Nelson Textbook of Pediatrics 22nd Edition | Human polyomaviruses (BKPyV, JCPyV) are ubiquitous, non-enveloped dsDNA viruses. Primary infection occurs in childhood (respiratory route), then latency in kidney/urothelium (BK) and CNS/lymphoid tissue (JC). Immunocompromised hosts: BKPyV β†’ hemorrhagic cystitis (HSCT) and BK virus-associated nephropathy (BKVAN) in renal transplant; JCPyV β†’ progressive multifocal leukoencephalopathy (PML). No specific antiviral; management: reduction of immunosuppression.

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πŸ“‹ 30 Clinical Scenarios β€” Polyomaviruses (BK & JC)

πŸ“‡ High‑Yield Review Cards (Polyomaviruses)

🩺 Recognizing Polyomavirus-Related Disease

Select a clinical presentation for diagnosis and management.

πŸ“‹ Step‑by‑Step Management of Polyomavirus Infections

    πŸ’Š Management by Condition

    Condition / VirusManagement / Key Actions

    ⚑ Clinical Reflex Prompts β€” Polyomaviruses

    πŸ“– Complete Summary: Polyomaviruses (Nelson Chapter 321)