Nelson Textbook of Pediatrics 22nd Edition | Roseola infantum (exanthem subitum, sixth disease). Caused by HHV-6B (most common, 90%) and HHV-7. Classic presentation: high fever (39-40°C) for 3-5 days in infant/toddler (6 months-2 years). Fever resolves abruptly, then rash appears (rose-pink maculopapular, starts on trunk, spreads to face/extremities). Complications: febrile seizures (common, 10-15%), encephalitis (rare). Diagnosis: clinical. Treatment: supportive (antipyretics, hydration). No antiviral needed.
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