Nelson Textbook of Pediatrics 22nd Edition | Yellow fever is a mosquito-borne flavivirus endemic in tropical Africa and South America. Clinical spectrum: mild febrile illness → severe disease with jaundice, hemorrhage, renal failure, and hepatic necrosis (Councilman bodies). Prevention: live-attenuated 17D vaccine (effective, lifelong immunity). No specific antiviral; supportive care only. High fatality (20-50%) in severe cases.
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