Nelson Textbook of Pediatrics 22nd Edition | Primary ovarian insufficiency (hypergonadotropic hypogonadism). Causes: Turner syndrome (45,X), 46,XX gonadal dysgenesis, Swyer syndrome (46,XY), chemotherapy/radiation, autoimmune oophoritis, FSH receptor mutations. Diagnosis: high FSH, low estradiol. Treatment: estrogen and progesterone replacement.
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