🧠 640.5 · Myelin Oligodendrocyte Glycoprotein–Associated Disorders (MOGAD)

Nelson Textbook of Pediatrics 22nd Edition | MOG antibody-associated disease (MOGAD). Phenotypes: ADEM (young children), optic neuritis (bilateral, papillitis, perineural enhancement), transverse myelitis (LETM, H-sign), NMOSD-like, cortical encephalitis. Monophasic in ~2/3, relapsing in ~1/3. Treatment: acute (IV steroids, IVIG), long-term immunosuppression (mycophenolate mofetil, rituximab, IVIG) for relapsing disease. Avoid MS therapies (interferon, fingolimod).