Nelson Textbook of Pediatrics 22nd Edition | Acute inflammation of the spinal cord. Clinical: bilateral motor weakness, sensory loss (sensory level), bowel/bladder dysfunction. MRI: spinal cord T2 hyperintensity. Short segment (<3 vertebral segments) + brain lesions → multiple sclerosis. Longitudinally extensive transverse myelitis (LETM, ≥3 segments) → NMOSD (AQP4) or MOGAD. Treatment: IV methylprednisolone, plasma exchange.
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